Leukemia and Alkylating Agents

 

FDA Approval for Bendamustine - from NCI.

Chronic Lymphocytic Leukemia - from NCI

Leukemia and Lymphoma Society

Alkylating agent definition

Chempedia on alkylating agents

Mayo Clinic on leukemia

The action of alkylating agents as chemotherapeutic drugs comes from their ability irreversibly bind to DNA and, once bound, the altered molecule disrupts the normal action and replication of the DNA strand. When this alkylation takes place at several places along the DNA molecule, the normal processes of the cell are interrupted. This leads to either to programmed cell death (apoptosis) or at least an arrest in cellular replication. In either case, when applied to cancer cells, alkylating agents can limit tumor growth and lead to tumor destruction.

 

 

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